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Literature summary for 1.2.1.24 extracted from

  • Ryzlak, M.T.; Pietruszko, R.
    Human brain high Km aldehyde dehydrogenase: purification, characterization, and identification as NAD+-dependent succinic semialdehyde dehydrogenase (1988), Arch. Biochem. Biophys., 266, 386-396.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Disulfiram
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007 0.002 succinate semialdehyde
-
Homo sapiens
0.04
-
NAD+
-
Homo sapiens
0.58
-
propionaldehyde
-
Homo sapiens
0.875
-
acetaldehyde
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
x * 61000 + x * 63000, SDS-PAGE Homo sapiens
63000
-
x * 61000 + x * 63000, SDS-PAGE Homo sapiens
200000
-
gel filtration Homo sapiens
232000 245000 non-denaturing PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O 2.3% of the activity with succinate semialdehyde Homo sapiens acetate + NADH + H+
-
?
glutaric semialdehyde + NAD+ + H2O 13% of the activity with succinate semialdehyde Homo sapiens glutarate + NADH
-
?
m-nitrobenzaldehyde + NAD+ + H2O 4.3% of the activity with succinate semialdehyde Homo sapiens m-nitrobenzoate + NADH
-
?
p-nitrobenzaldehyde + NAD+ + H2O 6.5% of the activity with succinate semialdehyde Homo sapiens p-nitrobenzoate + NADH
-
?
propionaldehyde + NAD+ + H2O 5% of the activity with succinate semialdehyde Homo sapiens propionate + NADH
-
?
succinate semialdehyde + NAD+ + H2O
-
Homo sapiens succinate + NADH
-
?

Subunits

Subunits Comment Organism
? x * 61000 + x * 63000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens