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Literature summary for 1.2.1.23 extracted from

  • Bender, K.; Seibert, R.T.; Wienker, T.F.; Kren, V.; Pravenec, M.; Bissbort, S.
    Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus) (1994), Biochem. Genet., 32, 147-154.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
detection of two Mgd loci, which show a restrictive tissue expression, Mgd1 and Mgd2 are preferentially expressed in liver and kidney Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + NAD+ + H2O Rattus norvegicus
-
pyruvate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
inbred strains, recombinant inbred strains
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoaldehydes + NAD+ + H2O
-
Rattus norvegicus 2-oxo acids + NADH
-
?
methylglyoxal + NAD+ + H2O
-
Rattus norvegicus pyruvate + NADH + H+
-
?

Subunits

Subunits Comment Organism
tetramer 4 * ?, codominant expression is observed in heterozygotes providing evidence for this enzyme structure Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+ Mgd1 and Mgd2 enzymes use also NADP+ as cofactor, see also EC 1.2.1.49 Rattus norvegicus