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Literature summary for 1.2.1.23 extracted from
- On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase (1982), J. Biol. Chem., 257, 10571-10574.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dihydroxyacetone phosphate | stimulation | Capra hircus |  |
| fructose 1,6-bisphosphate | 100% stimulation, 0.03 mM, extent of stimulation is pH-dependent | Capra hircus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | strong inhibitor, 1 mM | Capra hircus | |
| ATP | strong inhibitor, 0.6 mM | Capra hircus | |
| glyceraldehyde 3-phosphate | strong inhibitor | Capra hircus | |
| GTP | strong inhibitor, 1 mM | Capra hircus | |
| NADP+ | strong competitive inhibitor, 0.001 mM | Capra hircus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylglyoxal + NAD+ + H2O | Capra hircus | i.e. pyruvaldehyde | pyruvate + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoaldehydes + NAD+ + H2O | - |
Capra hircus | 2-oxo acids + NADH | - |
? | |
| methylglyoxal + NAD+ + H2O | i.e. pyruvaldehyde | Capra hircus | pyruvate + NADH + H+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Capra hircus | |
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Release 2023.1 (January 2023)
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