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Literature summary for 1.2.1.21 extracted from

  • Tani, Y.; Morita, H.; Nishise, H.; Ogata, K.
    Separation and characterization of glycolaldehyde dehydrogenase isozymes in Escherichia coli B (1978), Agric. Biol. Chem., 42, 63-68.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Al3+ 1 mM, isozyme A, 26% inhibition Escherichia coli
As3+ 1 mM, isozyme A, 42% inhibition, isozyme B, 11% inhibition, isozyme C, 55% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3 Escherichia coli
Ca2+ 1 mM, isozyme A, 42% inhibition, isozyme B, 32% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3 Escherichia coli
Co2+ 1 mM, isozyme A, 71% inhibition, isozyme B, 51% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3 Escherichia coli
Fe2+ 1 mM, isozyme A, 18% inhibition Escherichia coli
HgCl2 1 mM, complete inhibition of isozymes A, B, and C Escherichia coli
KCN isozymes A and C Escherichia coli
Mg2+ 1 mM, isozyme A, 33% inhibition, isozyme B, 54% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3 Escherichia coli
Mn2+ 1 mM, isozyme A, 20% inhibition, isozyme C, 44% inhibition Escherichia coli
monoiodoacetate 1 mM, isozymes A, 83% inhibition, isozyme C, 100% inhibition Escherichia coli
MoO22- 1 mM, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3 Escherichia coli
Zn2+ 1 mM, isozyme A, 30% inhibition Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
isozyme B, gel filtration Escherichia coli
225000
-
isozyme A, gel filtration Escherichia coli
345000
-
isozyme C, gel filtration Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B WG1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial: isozymes A, B and C Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7
-
isozyme B Escherichia coli
2.75
-
isozyme C Escherichia coli
3.66
-
isozyme A Escherichia coli
6.38
-
isozyme A from pyridoxine auxotroph strain WG3 Escherichia coli

Storage Stability

Storage Stability Organism
-20°C Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O reverse reaction, isozyme A, 188% of activity with glycolate, isozyme B, 112%, isozyme C, 74% Escherichia coli acetate + NADH + H+
-
r
acetaldehyde + NAD+ + H2O reverse reaction, isozyme A, 188% of activity with glycolate, isozyme B, 112%, isozyme C, 74% Escherichia coli B WG1 acetate + NADH + H+
-
r
benzaldehyde + NAD+ + H2O isozyme A, 195% of activity with glycolate in reverse reaction Escherichia coli benzoate + NADH + H+
-
?
benzaldehyde + NAD+ + H2O isozyme A, 195% of activity with glycolate in reverse reaction Escherichia coli B WG1 benzoate + NADH + H+
-
?
betaine + NADH isozyme A 139% of activity with glycolate, isozyme B, 76% Escherichia coli betaine aldehyde + NAD+ + H2O glucono-delta-lactone is not used as substrate ?
formate + NADH isozyme A, 163% of activity with glycolate Escherichia coli methanal + NAD+
-
?
glycolaldehyde + NAD+ + H2O
-
Escherichia coli glycolate + NADH
-
r
glycolaldehyde + NAD+ + H2O
-
Escherichia coli B WG1 glycolate + NADH
-
r
glyoxylate + NADH isozyme A, 417% of activity with glycolate, isozyme B 714%, isozyme C 150% Escherichia coli glyoxal + NAD+
-
?
malonate + NADH isozyme A, 83% of activity with glycolate Escherichia coli malonic semialdehyde + NAD+ + H2O
-
?
oxalate + NADH isozyme A, 167% of activity with glycolate, isozyme B, 71% Escherichia coli glyoxylate + NAD+
-
?
oxalate + NADH isozyme A, 167% of activity with glycolate, isozyme B, 71% Escherichia coli B WG1 glyoxylate + NAD+
-
?
succinate + NADH isozyme A, 146% of activity with glycolate, isozyme B 6% Escherichia coli succinic semialdehyde + NAD+ + H2O
-
?
succinate + NADH isozyme A, 146% of activity with glycolate, isozyme B 6% Escherichia coli B WG1 succinic semialdehyde + NAD+ + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
isozyme A Escherichia coli
30
-
isozyme A from strain WG3 Escherichia coli
45
-
isozymes B and C Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
glycolate reduction, isozyme A, B Escherichia coli
5.4
-
isozyme A, glycolaldehyde oxidation Escherichia coli
6
-
glycolate reduction, isozyme C Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Escherichia coli