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Literature summary for 1.2.1.13 extracted from

  • Bae, B.I.; Hara, M.R.; Cascio, M.B.; Wellington, C.L.; Hayden, M.R.; Ross, C.A.; Ha, H.C.; Li, X.J.; Snyder, S.H.; Sawa, A.
    Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH (2006), Proc. Natl. Acad. Sci. USA, 103, 3405-3409.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.13

Application

Application Comment Organism
medicine results suggest that GAPDH may have a common role in modulating the pathophysiology of polyQ diseases like the Huntington desease Mus musculus
medicine results suggest that GAPDH may have a common role in modulating the pathophysiology of polyQ diseases like the Huntington desease Homo sapiens

Protein Variants

Protein Variants Comment Organism
K225A K225 is critical for binding of GAPDH to Siah1, an ubiquitin-E3-ligase, eliciting the translocation of GAPDH to the nucleus Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Homo sapiens 5829
-
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
Neuro-2a cell mouse neuroblastoma cell line Mus musculus
-

Synonyms

Synonyms Comment Organism
GAPDH
-
 Mus musculus
GAPDH
-
 Homo sapiens
glyceraldehyde-3-phosphate dehydrogenase
-
 Mus musculus
glyceraldehyde-3-phosphate dehydrogenase
-
 Homo sapiens