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Literature summary for 1.2.1.12 extracted from

  • Freitas, R.F.; Prokopczyk, I.M.; Zottis, A.; Oliva, G.; Andricopulo, A.D.; Trevisan, M.T.; Vilegas, W.; Silva, M.G.; Montanari, C.A.
    Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors (2009), Bioorg. Med. Chem., 17, 2476-2482.
    View publication on PubMed
Search for more literature for 1.2.1.12

Inhibitors

Inhibitors Comment Organism Structure
(8E,11E)-C15:2-anacardic acid
-
 Trypanosoma cruzi
(8E,11E,14E)-C15:3-anacardic acid
-
 Trypanosoma cruzi
(E)-2-hydroxy-6-(pentadec-8-en-1-yl)benzoic acid
-
 Trypanosoma cruzi
guajaverin molecular docking studies. Guajaverin is stabilized by five hydrogen bonds with the amino acids Ser165, Thr226, Arg249, Ser134, and Glu336 Trypanosoma cruzi
mangiferin
-
 Trypanosoma cruzi
quercetin molecular docking studies. Quercetin is stabilized by two hydrogen bonds with the amino acids Ala198 and Pro253 Trypanosoma cruzi
tiliroside molecular docking studies. Tiliroside is stabilized by four hydrogen bonds with the amino acids Cys166, Ser134, and Ser110 Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi P22513
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Trypanosoma cruzi 3-phospho-D-glyceroyl phosphate + NADH
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.038
-
 pH 7.5, 25°C Trypanosoma cruzi (8E,11E,14E)-C15:3-anacardic acid
0.046
-
 pH 7.5, 25°C Trypanosoma cruzi tiliroside
0.069
-
 pH 7.5, 25°C Trypanosoma cruzi (8E,11E)-C15:2-anacardic acid
0.14
-
 pH 7.5, 25°C Trypanosoma cruzi guajaverin
0.142
-
 pH 7.5, 25°C Trypanosoma cruzi quercetin
0.149
-
 pH 7.5, 25°C Trypanosoma cruzi mangiferin
0.161
-
 pH 7.5, 25°C Trypanosoma cruzi (8E)-C15:1-anacardic acid