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Literature summary for 1.2.1.11 extracted from

  • Arachea, B.T.; Liu, X.; Pavlovsky, A.G.; Viola, R.E.
    Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog (2010), Acta Crystallogr. Sect. D, 66, 205-212.
    View publication on PubMed
Search for more literature for 1.2.1.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Candida albicans

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 20% (w/v) PEG 400, 0.1 M HEPES pH 6.5, 0.1 M MgCl2, at 20°C Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+ Candida albicans
-
 L-4-aspartyl phosphate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans Q5ALM0
-
-

Purification (Commentary)

Purification (Comment) Organism
cobalt immobilized metal-affinity column chromatography and Source 30Q column chromatography Candida albicans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Candida albicans L-4-aspartyl phosphate + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Candida albicans

Synonyms

Synonyms Comment Organism
ASADH
-
 Candida albicans
aspartate semialdehyde dehydrogenase
-
 Candida albicans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.12
-
 L-aspartate 4-semialdehyde pH and temperature not specified in the publication Candida albicans

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Candida albicans