Literature summary for 1.2.1.11 extracted from

Holland, M.J.; Westhead, E.W.
Adenosine 5-triphosphate induced cold inactivation of yeast aspartic -semialdehyde dehydrogenase (1973), Biochemistry, 12, 2270-2275.

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General Stability

General Stability	Organism
adenosine 5'-triphosphate, time dependent inactivation at 0°C	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
adenosine 5'-triphosphate	causes a time-dependent inactivation at a concentration of 3.5 mM, 0°C, pH 6.5 and 2 mM dithiothreitol, inactivation can be completely reversed by warming the reaction mixture to 25°C, 50% inactivation occurs at a concentration of 2.5 mM, NADH protects	Saccharomyces cerevisiae
additional information	-	Saccharomyces cerevisiae
NADPH-Tris-chloride buffer	promotes a weak inactivation at 0°C, NADH protects	Saccharomyces cerevisiae
potassium phosphate	at a concentration of 10 mM promotes 60% inactivation at 0°C in the presence of 10 mM ATP, at a concentration of 100 mM promotes 61% inactivation in the presence of 10 mM ATP and 32% inactivation in the absence of ATP, NADH protects	Saccharomyces cerevisiae
Tris salts	100 mM promotes 60.5% inactivation in the presence of 10 mM ATP and 17% inactivation in the absence of ATP	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Saccharomyces cerevisiae	L-4-aspartyl phosphate + NADPH	-	?

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Release 2023.1 (January 2023)