Literature summary for 1.2.1.104 extracted from

Wei, T.; Huang, G.; Liu, P.; Gao, J.; Huang, C.; Sun, M.; Shen, W.
Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions (2019), Cell Death Dis., 10, 614 .

Search for more literature for 1.2.1.104

Application

Application	Comment	Organism
medicine	high salt intake downregulates sirtuin SIRT3 level in brown adipose tissue, accompanied by decreased oxygen consumption rate, and causes a severe loss of brown adipose tissue characteristics. SIRT3 interacts with pyruvate dehydrogenase E1alpha (PDHA1) and deacetylates residue Lys83 both in vitro and in vivo under high salt intake. In parallel, high salt intake suppresses salt-induced kinase (Sik) 2 phosphorylation. Silencing Sik2 further diminishes SIRT3 activity and enhances acetylation of PDHA1 K83. Reconstruction of SIRT3 restores PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P35486	E1 component subunit alpha	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	brown adipocyte	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	high salt intake downregulates sirtuin SIRT3 level in brown adipose tissue, accompanied by decreased oxygen consumption rate, and causes a severe loss of brown adipose tissue characteristics. SIRT3 interacts with pyruvate dehydrogenase E1alpha (PDHA1) and deacetylates residue Lys83 both in vitro and in vivo under high salt intake. In parallel, high salt intake suppresses salt-induced kinase (Sik) 2 phosphorylation. Silencing Sik2 further diminishes SIRT3 activity and enhances acetylation of PDHA1 K83. Reconstruction of SIRT3 restores PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout mice	Mus musculus

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Release 2023.1 (January 2023)