Literature summary for 1.2.1.104 extracted from

Klyuyeva, A.; Tuganova, A.; Kedishvili, N.; Popov, K.M.
Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex (2019), J. Biol. Chem., 294, 838-851 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P35486 and Q9D051	P35486 i.e. E1 component subunit alpha, Q9D051 i.e. E1 component subunit beta	-

General Information

General Information	Comment	Organism
physiological function	the activity of PDC is regulated by different isozymes of pyruvate dehydrogenase kinase PDK in different tissues. Isoform PDK1 is the principal isozyme regulating hepatic PDC. PDK2 is largely responsible for inactivation of PDC in tissues of muscle origin and brown adipose tissue (BAT). PDK3 is the principal kinase regulating pyruvate dehydrogenase activity in kidney and brain. In a well-fed state, the tissue levels of PDK4 protein are fairly low. In most tissues tested, PDK4 ablation has little effect on the overall rates of inactivation of PDC in kinase reaction	Mus musculus

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Release 2023.1 (January 2023)