Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | required | Rattus norvegicus | |
GTP | stimulates to a lesser degree than ATP | Rattus norvegicus | |
ITP | stimulates to a lesser degree than ATP | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | oxygen may be obligatory since there is almost complete inhibition when the reaction is performed in an atmosphere consisting of nitrogen | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor | conversion of the coenzyme A ester is lower than with the free acid as substrate | Rattus norvegicus | 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor | - |
? | |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + H2O + acceptor | - |
Rattus norvegicus | 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoic acid + reduced acceptor | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | pH 6.5: about 30% of maximal activity, pH 8.5: about 60% of maximal activity | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
coenzyme A | marked inhibition of reaction with 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid | Rattus norvegicus | |
FMN | slight | Rattus norvegicus |