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Literature summary for 1.17.4.4 extracted from

  • Perez-Andreu, V.; Teruel, R.; Corral, J.; Roldan, V.; Garcia-Barbera, N.; Salloum-Asfar, S.; Gomez-Lechon, M.J.; Bourgeois, S.; Deloukas, P.; Wadelius, M.; Vicente, V.; Gonzalez-Conejero, R.; Martinez, C.
    miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle (2012), Mol. Med., 18, 1466-1472.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.4.4

Application

Application Comment Organism
medicine the enzyme is regulated by microRNA miR-133a, which may have potential importance for anticoagulant therapy or aortic calcification Homo sapiens
medicine vitamin K 2,3-epoxide reductase complex subunit 1 is is the target of oral anticoagulant drugs and a relevant molecule for cardiovascular diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene rs9923231 or VKORC1, genotyping of rs9923231, quantitative RT-PCR expression analysis Homo sapiens
gene rs9923231, quantitative reverse transcriptase–PCR expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
miR-133a micro-RNA, miR-133a interacts with the 3'-UTR of VKORC1. Transfection of miRNA precursors of miR-133a in HepG2 cells reduces VKORC1 mRNA expression in a dose-dependent manner, quantitative RT-PCR expression analysis, overview. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects. In silico identification of VKORC1 miRNA binding sites, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Homo sapiens
-
 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6BQB6 gene rs9923231 or VKORC1
-
Homo sapiens Q9BQB6 gene rs9923231
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
 Homo sapiens 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
 ?

Synonyms

Synonyms Comment Organism
vitamin K 2,3-epoxide reductase complex subunit 1
-
 Homo sapiens
VKORC1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens miR-133a miRNA targeting the enzyme in HepG2 cells reduces VKORC1 mRNA expression in a dose-dependent manner, quantitative reverse transcriptase–polymerase chain reaction expression analysis. miR-133a interacts with the 3'-UTR of VKORC1 down
Homo sapiens micro-RNA miR-133a interacts with the 3'-UTR of VKORC1. Transfection of miRNA precursors of miR-133a in HepG2 cells reduces VKORC1 mRNA expression. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects down

General Information

General Information Comment Organism
physiological function the enzyme is regulated by microRNA miR-133a, which may have potential importance for anticoagulant therapy or aortic calcification. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects Homo sapiens
physiological function VKORC1 is an essential element involved in the correct gamma-carboxylation of vitamin K-dependent proteins such as Gas6, matrix-GLA protein and osteocalcin, as well as hemostatic proteins C, S and Z and coagulation factors II, VII, IX and X. vitamin K 2,3-epoxide reductase complex subunit 1, VKORC1, is a key protein in the vitamin K cycle, it is regulated by microRNA miR-133a, overview. Vitamin K 2,3-epoxide reductase complex subunit 1 is a relevant molecule for cardiovascular diseases, since it plays a role in soft tissue calcification Homo sapiens