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Literature summary for 1.17.4.4 extracted from
- Vitamin K-dependent carboxylation (2008), Vitam. Horm., 78, 131-156.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S57A | the mutation eliminates VKOR activity | Homo sapiens |
| W57A | the mutation eliminates VKOR activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| warfarin | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| oxidation of the active site thiols during KO reduction inactivates VKOR | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| vitamin K 2,3-epoxide + dithiothreitol | - |
Homo sapiens | vitamin K + oxidized dithiothreitol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| vitamin K oxidoreductase | - |
Homo sapiens |
| VKOR | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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