Protein Variants | Comment | Organism |
---|---|---|
Y139F | highly resistant to warfarin and increased resistance to further anticoagulants | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
brodifacoum | - |
Rattus norvegicus | |
bromadiolone | - |
Rattus norvegicus | |
chlorophacinone | - |
Rattus norvegicus | |
coumachlor | - |
Rattus norvegicus | |
coumatetralyl | - |
Rattus norvegicus | |
Difenacoum | - |
Rattus norvegicus | |
diphacinone | - |
Rattus norvegicus | |
warfarin | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
brodifacoum | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00007 | - |
Difenacoum | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00007 | - |
diphacinone | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00008 | - |
chlorophacinone | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00009 | - |
brodifacoum | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.00012 | - |
coumachlor | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00013 | - |
bromadiolone | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00013 | - |
coumatetralyl | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00026 | - |
Difenacoum | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.00072 | - |
warfarin | wild-type, pH 7.4, 30°C | Rattus norvegicus | |
0.00091 | - |
bromadiolone | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.0016 | - |
chlorophacinone | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.0019 | - |
coumachlor | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.0031 | - |
coumatetralyl | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.005 | - |
diphacinone | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus | |
0.029 | - |
warfarin | mutant Y139F, pH 7.4, 30°C | Rattus norvegicus |