Literature summary for 1.17.4.4 extracted from

Schelleman, H.; Chen, Z.; Kealey, C.; Whitehead, A.S.; Christie, J.; Price, M.; Brensinger, C.M.; Newcomb, C.W.; Thorn, C.F.; Samaha, F.F.; Kimmel, S.E.
Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and Caucasians (2007), Clin. Pharmacol. Ther., 81, 742-747.

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Application

Application	Comment	Organism
medicine	comparison of the effect of single nucleotide polymorphisms in African Americans and Caucasians. Subjects carrying an 1173T allele have a lower warfarin maintenance compared with subjects with the CC genotype in African americans and Caucasians. Before reaching maintenance dose, only Caucasians with the T allele have significantly increased risk of international normlized ratio > 3 compared with Caucasians with the CC genotype. Polymorphisms may not be useful in predicting over-coagulation among African Americans	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)