Literature summary for 1.17.4.4 extracted from

Wang, D.; Chen, H.; Momary, K.M.; Cavallari, L.H.; Johnson, J.A.; Sadee, W.
Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement (2008), Blood, 112, 1013-1021.

Search for more literature for 1.17.4.4

Application

Application	Comment	Organism
medicine	the single nucleotide polymorphism G1639A is a suitable biomarker for warfarin dosing across ethnic populations. Preferential association of the promoter -1639 G allele with active chromatin	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	in vitro expression of VKORC1 gene constructs, including coding region and promoter, fails to reveal any genotype effect on transcription and mRNA processing	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BQB6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	measurement of allelic mRNA expression	Homo sapiens	-
liver	measurement of allelic mRNA expression. Genotype effect of 2-fold allelic mRNA expression due to single nucleotide polymorphisms -1639G>A and 1173C	Homo sapiens	-
lymphocyte	B lymphocyte, measurement of allelic mRNA expression	Homo sapiens	-

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Release 2023.1 (January 2023)