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Literature summary for 1.17.4.4 extracted from

  • Tie, J.K.; Nicchitta, C.; von Heijne, G.; Stafford, D.W.
    Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation (2005), J. Biol. Chem., 280, 16410-16416.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of different constructs of N- or C-terminally NST-tagged or HPC4-tagged enzyme in insect cells, the NST tag is an N-linked glycosylation tag without a flexible linker, ER membrane topology of the recombinant enzymes, the tagged enzyme is glycosylated, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane membrane topology, type III membrane protein, overview Homo sapiens 5789
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Homo sapiens i.e. vitamin K 2,3-epoxide 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. vitamin K ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol i.e. vitamin K 2,3-epoxide Homo sapiens 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. vitamin K ?

Synonyms

Synonyms Comment Organism
vitamin K epoxide reductase
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Homo sapiens
VKOR
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Homo sapiens