Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-hydroxyimidazopyridine | 4.0 mM, 9% inhibition, warfarin-resistant rats | Rattus norvegicus | |
2,3,5,6-Tetrachloro-4-pyridinol | 2.0 mM, 45% inhibition, warfarin-resistant rats | Rattus norvegicus | |
coumarin anticoagulants | - |
Rattus norvegicus | |
Imidazopyridines | - |
Rattus norvegicus | |
warfarin | 0.01 mM, 18% inhibition, 0.1 mM, 64% inhibition, warfarin-resistant rats | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
microsome | integral membrane protein | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus Holtzman | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
Holtzman strain | - |
Rattus norvegicus Holtzman | - |
Holtzman strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Storage Stability | Organism |
---|---|
4°C, acetone powder, stable | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. 3-hydroxy-2,3-dihydro-vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Rattus norvegicus Holtzman | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus Holtzman | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. 3-hydroxy-2,3-dihydro-vitamin K | ? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus Holtzman | vitamin K + oxidized dithiothreitol | - |
? |