Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.4.2 extracted from

  • Logan, D.
    Closing the circle on ribonucleotide reductases (2011), Nat. Struct. Mol. Biol., 18, 251-253.
    View publication on PubMed
Search for more literature for 1.17.4.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside 5'-triphosphate + thioredoxin Salmonella enterica subsp. enterica serovar Typhimurium class III RNR 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
 ?
nucleoside 5'-triphosphate + thioredoxin Escherichia coli class III RNR 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
 ?
nucleoside 5'-triphosphate + thioredoxin Pseudomonas aeruginosa class III RNR 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Pseudomonas aeruginosa
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information In class II a tyrosine radical is generated directly on alpha or alpha2 by cleavage of adenosylcobalamin. In class III a glycyl radical is generated on alpha2 when a radical SAM protein cleaves S-adenosylmethionine. In both cases, the radical is channeled to a cysteine in the active site of the alpha subunit to initiate catalysis Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
additional information In class II a tyrosine radical is generated directly on alpha or alpha2 by cleavage of adenosylcobalamin. In class III a glycyl radical is generated on alpha2 when a radical SAM protein cleaves S-adenosylmethionine. In both cases, the radical is channeled to a cysteine in the active site of the alpha subunit to initiate catalysis Escherichia coli ?
-
 ?
additional information In class II a tyrosine radical is generated directly on alpha or alpha2 by cleavage of adenosylcobalamin. In class III a glycyl radical is generated on alpha2 when a radical SAM protein cleaves S-adenosylmethionine. In both cases, the radical is channeled to a cysteine in the active site of the alpha subunit to initiate catalysis Pseudomonas aeruginosa ?
-
 ?
nucleoside 5'-triphosphate + thioredoxin class III RNR Salmonella enterica subsp. enterica serovar Typhimurium 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
 ?
nucleoside 5'-triphosphate + thioredoxin class III RNR Escherichia coli 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
 ?
nucleoside 5'-triphosphate + thioredoxin class III RNR Pseudomonas aeruginosa 2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
 ?

Subunits

Subunits Comment Organism
monomer or dimer class II enzymes show a monomeric or dimeric structure Escherichia coli
More structures of the active holoenzymes of class I-III RNRs, structure comparisons, overview Salmonella enterica subsp. enterica serovar Typhimurium
More structures of the active holoenzymes of class I-III RNRs, structure comparisons, overview Escherichia coli
More structures of the active holoenzymes of class I-III RNRs, structure comparisons, overview Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
class III RNR
-
 Salmonella enterica subsp. enterica serovar Typhimurium
class III RNR
-
 Escherichia coli
class III RNR
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
additional information RNRs are allosterically regulated on two levels, overall activity and substrate specificity. The substrate specificity is regulated by the binding of dNTPs to the specificity site, ATP and dATP upregulate the reduction of CDP and UDP, whereas dTTP upregulates GDP reduction and dGTP increases the rate of ADP reduction. This regulation is essential to maintain balanced dNTP pools for DNA synthesis and repairI Salmonella enterica subsp. enterica serovar Typhimurium
additional information RNRs are allosterically regulated on two levels, overall activity and substrate specificity. The substrate specificity is regulated by the binding of dNTPs to the specificity site, ATP and dATP upregulate the reduction of CDP and UDP, whereas dTTP upregulates GDP reduction and dGTP increases the rate of ADP reduction. This regulation is essential to maintain balanced dNTP pools for DNA synthesis and repairI Escherichia coli
additional information RNRs are allosterically regulated on two levels, overall activity and substrate specificity. The substrate specificity is regulated by the binding of dNTPs to the specificity site, ATP and dATP upregulate the reduction of CDP and UDP, whereas dTTP upregulates GDP reduction and dGTP increases the rate of ADP reduction. This regulation is essential to maintain balanced dNTP pools for DNA synthesis and repairI Pseudomonas aeruginosa