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Literature summary for 1.17.4.2 extracted from
- Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, in adults with advanced hematologic malignancies (2007), Leuk. Res., 31, 1165-1173.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| triapine | a potent ribonucleotide reductase inhibitor, phase I and pharmacokinetic study in adults with advanced hematologic malignancies, detailed overview | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside triphosphate + thioredoxin | Homo sapiens | - |
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside triphosphate + thioredoxin | - |
Homo sapiens | 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | alpha2beta2 heterodimer with a regulatory, nucleotide binding site M1 subunit, and an inducible, catalytic M2 subunit which contains non-heme iron and a tyrosyl free radical, that are required for the enzymatic reduction of ribonucleotides | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ribonucleotide reductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Homo sapiens | |
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