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Literature summary for 1.17.4.2 extracted from

  • Hakansson, P.; Hofer, A.; Thelander, L.
    Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells (2006), J. Biol. Chem., 281, 7834-7841.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
BALB/3T3 cell fibroblast cell, non-dividing cells expressing enzyme subunit p53R2, but not sunit R2 protein, have reduced dNTP levels if exposed to the enzyme--specific inhibitor hydroxyurea. After DNA damage, a slow, up to 4fold increase in p53R2 expression leads to 3fold increase in dNTP pools in G0/G1 cells Mus musculus
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