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Literature summary for 1.17.4.2 extracted from

  • Torrents, E.; Poplawski, A.; Sjoberg, B.M.
    Two proteins mediate class II ribonucleotide reductase activity in Pseudomonas aeruginosa: expression and transcriptional analysis of the aerobic enzymes (2005), J. Biol. Chem., 280, 16571-16578.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa the two-component class II RNR is primarily used for DNA repair and/or possibly DNA replication at low oxygen tension. It can support bacterial growth in the absence of class I RNR activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information exponentialy grown cells predominantly express class I enzyme compared with class II enzyme, activity in stationary phase cells Pseudomonas aeruginosa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + reduced thioredoxin
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 Pseudomonas aeruginosa dCTP + thioredoxin disulfide + H2O
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 ?
additional information the two-component class II RNR is primarily used for DNA repair and/or possibly DNA replication at low oxygen tension. It can support bacterial growth in the absence of class I RNR activity Pseudomonas aeruginosa ?
-
 ?

Subunits

Subunits Comment Organism
More the enzyme is encoded by two consecutive open reading frames denated nrdJa and nrdJb and separated by 16 bp. The presence of both NrdJa and NrdJb subunits is absolutely essential for enzyme activity Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
class II RNR
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 Pseudomonas aeruginosa