Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | allosteric effector of CDP reaction | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | ribonucleotide reductase is a key enzyme in DNA synthesis and cell growth control and represents an excellent target for anticancer therapy. 5'-O-valproyl-3'-C-methyladenosine inhibits ribonucleotide reductase activity by competing with ATP as an allosteric effector and concomitantly reduces the intracellular deoxyribonucleoside triphosphate pools. In contrast to previously used ribonucleotide reductase nucleoside analogs does not require intracellular kinases for its activity and therefore holds promise against drug resistant tumors with downregulated nucleoside kinases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-O-valproyl-3'-C-methyladenosine | inhibits ribonucleotide reductase activity by competing with ATP as an allosteric effector and concomitantlyreduces the intracellular deoxyribonucleoside triphosphate pools. In contrast to previously used ribonucleotide reductase nucleoside analogs does not require intracellular kinases for its activity and therefore holds promise against drug resistant tumors with downregulated nucleoside kinases | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23921 | ribonucleoside-diphosphate reductase large subunit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + thioredoxin | - |
Homo sapiens | 2'-dADP + thioredoxin disulfide + H2O | - |
? | |
CDP + thioredoxin | - |
Homo sapiens | 2'-dCDP + thioredoxin disulfide + H2O | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
5'-O-valproyl-3'-C-methyladenosine | pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | key enzyme in DNA synthesis and cell growth control | Homo sapiens |