Application | Comment | Organism |
---|---|---|
medicine | thiosemicarbazone chelators 2-[di(pyridin-2-yl)methylidene]-N,N-dimethylhydrazinecarbothioamide and 2-(diphenylmethylidene)-N,N-dimethylhydrazinecarbothioamide possess potent and selective antitumor activity and may have an additional mechanism of ribonucleotide reductase inhibition via their effects on major thiol-containing systems | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(diphenylmethylidene)-N,N-dimethylhydrazinecarbothioamide | metal chelator, significantly decreases ribonucleotide reductase activity, whereas the NADPH/NADP+ total ratio is not reduced | Homo sapiens | |
2-[di(pyridin-2-yl)methylidene]-N,N-dimethylhydrazinecarbothioamide | metal chelator, significantly decreases ribonucleotide reductase activity, whereas the NADPH/NADP+ total ratio is not reduced | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DMS-53 cell | small cell lung carcinoma | Homo sapiens | - |
SK-N-MC cell | neuroepithelioma cell | Homo sapiens | - |