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Literature summary for 1.17.4.1 extracted from

  • Roa, H.; Lang, J.; Culligan, K.M.; Keller, M.; Holec, S.; Cognat, V.; Montane, M.H.; Houlne, G.; Chaboute, M.E.
    Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis (2009), Plant Physiol., 151, 461-471.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of AtRNR2-like catalytic subunit gene AtRNR2A, phylogenetic analysis. Transcriptional changes of 17-days-old Arabidopsis plants, enriched in S-phase cells over younger seedlings, in response to the replication-blocking agent hydroxyurea and to the DNA double-strand break inducer bleomycin Arabidopsis thaliana
expression analysis of AtRNR2-like catalytic subunit gene AtRNR2B, phylogenetic analysis. Transcriptional changes of 17-days-old Arabidopsis plants, enriched in S-phase cells over younger seedlings, in response to the replication-blocking agent hydroxyurea and to the DNA double-strand break inducer bleomycin Arabidopsis thaliana
expression analysis of the AtRNR2-like catalytic subunit gene TSO2, phylogenetic analysis. Transcriptional changes of 17-days-old Arabidopsis plants, enriched in S-phase cells over younger seedlings, in response to the replication-blocking agent hydroxyurea and to the DNA double-strand break inducer bleomycin Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information atTSO2 transcription is only activated in response to double-strand breaks dependent upon AtE2Fa. ATso2 mutant is hypersensitive to bleomycin, transgenic plant phenotypes, overview Arabidopsis thaliana
additional information early AtRNR2A induction is decreased in an atr mutant, rnr2a mutants are hypersensitive to hydroxyurea, transgenic plant phenotypes, overview Arabidopsis thaliana
morme AtRNR2B induction is abolished in the rad9-rad17 double mutant, transgenic plant phenotypes, overview Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana RNR is an essential enzyme that provides dNTPs for DNA replication and repair, regulation in response to genotoxic stress, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P0DKH2 small subunit B, R2B; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B
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Arabidopsis thaliana P50651 small subunit A, R2A; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B
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Arabidopsis thaliana Q9LSD0 small subunit C, TSO2; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNR is an essential enzyme that provides dNTPs for DNA replication and repair, regulation in response to genotoxic stress, overview Arabidopsis thaliana ?
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 ?

Synonyms

Synonyms Comment Organism
ribonucleotide reductase
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 Arabidopsis thaliana
RNR2
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 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function RNR is an essential enzyme that provides dNTPs for DNA replication and repair, AtRNR2A induction is likely required for the replicative stress checkpoint. Individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis thaliana Arabidopsis thaliana
physiological function RNR is an essential enzyme that provides dNTPs for DNA replication and repair, TSO2 and E2Fa are likely required for the DNA damage response. Individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis thaliana Arabidopsis thaliana
physiological function RNR is an essential enzyme that provides dNTPs for DNA replication and repair. Individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis thaliana Arabidopsis thaliana