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Literature summary for 1.17.4.1 extracted from

  • Nurbo, J.; Roos, A.K.; Muthas, D.; Wahlstroem, E.; Ericsson, D.J.; Lundstedt, T.; Unge, T.; Karlen, A.
    Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase (2007), J. Pept. Sci., 13, 822-832.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
Mycobacterium tuberculosis
DTT
-
Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
gene Rv3051c, expression of the His-tagged enzyme in Escherichia coli strain Bl21(DE3) Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
additional information synthesis and evaluation of peptide inhibitors of RNR derived from the C-terminus of the small subunit of Mycobacterium tuberculosis RNR, based on the heptapeptide Ac-Glu-Asp-Asp-Asp-Trp-Asp-Phe-OH with Trp5 and Phe7 being very important for inhibitory potency, overview Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP + thioredoxin Mycobacterium tuberculosis
-
2'-deoxyCDP + thioredoxin disulfide + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
strain strain H37Rv, gene Rv3051c
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nicke affinity chromatography and gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP + thioredoxin
-
Mycobacterium tuberculosis 2'-deoxyCDP + thioredoxin disulfide + H2O
-
?

Synonyms

Synonyms Comment Organism
RNR
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Mycobacterium tuberculosis