Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mycobacterium tuberculosis | |
DTT | - |
Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
gene Rv3051c, expression of the His-tagged enzyme in Escherichia coli strain Bl21(DE3) | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | synthesis and evaluation of peptide inhibitors of RNR derived from the C-terminus of the small subunit of Mycobacterium tuberculosis RNR, based on the heptapeptide Ac-Glu-Asp-Asp-Asp-Trp-Asp-Phe-OH with Trp5 and Phe7 being very important for inhibitory potency, overview | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP + thioredoxin | Mycobacterium tuberculosis | - |
2'-deoxyCDP + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
strain strain H37Rv, gene Rv3051c | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nicke affinity chromatography and gel filtration | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP + thioredoxin | - |
Mycobacterium tuberculosis | 2'-deoxyCDP + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNR | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Mycobacterium tuberculosis |