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Literature summary for 1.17.4.1 extracted from

  • Holmgren, A.
    Regulation of ribonucleotide reductase (1981), Curr. Top. Cell. Regul., 19, 47-76.
    View publication on PubMed
Search for more literature for 1.17.4.1

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
 Escherichia phage T2
ATP
-
 Enterobacteria phage T6
ATP
-
 Tequintavirus T5
ATP stimulation of UDP reduction Escherichia coli
ATP stimulation of UDP reduction Homo sapiens
ATP stimulation of UDP reduction Bos taurus
ATP stimulation of UDP reduction Oryctolagus cuniculus
ATP stimulation of UDP reduction Tequatrovirus T4
ATP stimulation of CDP reduction Escherichia coli
ATP stimulation of CDP reduction Homo sapiens
ATP stimulation of CDP reduction Rattus norvegicus
ATP stimulation of CDP reduction Bos taurus
ATP stimulation of CDP reduction Oryctolagus cuniculus
ATP stimulation of CDP reduction Tequatrovirus T4
dGTP
-
 Rattus norvegicus
dGTP
-
 Tequatrovirus T4
dGTP
-
 Escherichia phage T2
dGTP
-
 Enterobacteria phage T6
dGTP
-
 Tequintavirus T5
dGTP stimulation of ADP reduction Escherichia coli
dGTP stimulation of ADP reduction Homo sapiens
dGTP stimulation of ADP reduction Bos taurus
dGTP stimulation of ADP reduction Oryctolagus cuniculus
dTTP
-
 Escherichia phage T2
dTTP
-
 Enterobacteria phage T6
dTTP
-
 Tequintavirus T5
dTTP stimulation of GDP reduction Escherichia coli
dTTP stimulation of GDP reduction Homo sapiens
dTTP stimulation of GDP reduction Rattus norvegicus
dTTP stimulation of GDP reduction Bos taurus
dTTP stimulation of GDP reduction Oryctolagus cuniculus
dTTP stimulation of GDP reduction Tequatrovirus T4

Inhibitors

Inhibitors Comment Organism Structure
3,5-diamino-1H-1,2,4-triazole 0.001 mM, 50% inhibition of CDP and UDP reduction, 0.05 mM, 50% inhibition of ADP reduction Bos taurus
3,5-diamino-1H-1,2,4-triazole
-
 Homo sapiens
dATP 0.005 mM, 50% inhibition of CDP and UDP reduction, 0.005 mM, 50% inhibition of GDP and ADP reduction; inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction Bos taurus
dATP inhibition of ADP reduction Enterobacteria phage T6
dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction Escherichia coli
dATP inhibition of ADP reduction Escherichia phage T2
dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction Homo sapiens
dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction Oryctolagus cuniculus
dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction Rattus norvegicus
dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction Tequatrovirus T4
dATP inhibition of ADP reduction Tequintavirus T5
dGTP 0.05 mM, 50% inhibition of GDP reduction; 0.1 mM, 50% inhibition of CDP and UDP reduction; inhibition of UDP reduction Bos taurus
dGTP
-
 Enterobacteria phage T6
dGTP
-
 Escherichia coli
dGTP
-
 Escherichia phage T2
dGTP
-
 Homo sapiens
dGTP
-
 Oryctolagus cuniculus
dGTP inhibition of UDP reduction Rattus norvegicus
dGTP
-
 Tequatrovirus T4
dGTP
-
 Tequintavirus T5
dTTP inhibition of UDP reduction Bos taurus
dTTP
-
 Enterobacteria phage T6
dTTP inhibition of ADP reduction Escherichia coli
dTTP
-
 Escherichia phage T2
dTTP
-
 Homo sapiens
dTTP
-
 Oryctolagus cuniculus
dTTP inhibition of UDP reduction Rattus norvegicus
dTTP
-
 Tequatrovirus T4
dTTP
-
 Tequintavirus T5
EDTA
-
 Bos taurus
EDTA
-
 Escherichia coli
EDTA
-
 Homo sapiens
EDTA
-
 Rattus norvegicus
Hydroxyurea
-
 Bos taurus
Hydroxyurea
-
 Escherichia coli
Hydroxyurea
-
 Homo sapiens
Hydroxyurea
-
 Oryctolagus cuniculus
Hydroxyurea
-
 Rattus norvegicus
Hydroxyurea
-
 Tequatrovirus T4
Hydroxyurea
-
 Tequintavirus T5

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Enterobacteria phage T6
-
-
-
Escherichia coli
-
-
-
Escherichia phage T2
-
-
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Tequatrovirus T4
-
 enzyme induced in Escherichia coli by infection with bacteriophage T4
-
Tequintavirus T5
-
 may use triphosphates as substrates
-

Source Tissue

Source Tissue Comment Organism Textmining
Novikoff ascites tumor cell
-
 Rattus norvegicus
-
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin
-
 Escherichia coli 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Homo sapiens 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Rattus norvegicus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Bos taurus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Oryctolagus cuniculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Tequatrovirus T4 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Escherichia phage T2 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Enterobacteria phage T6 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
ribonucleoside diphosphate + reduced thioredoxin
-
 Tequintavirus T5 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir