Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides, in vitro, in silico, and in vivo studies, overview. No inhibition by N'-[(E)-(2-nitrophenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(4-nitrophenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(3-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-ethoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-methoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(3,4-dimethoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2,3,4-trimethoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-hydroxy-6-methoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-hydroxy-5-methoxyphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2,4-dichlorophenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-(2-hydroxy-5-methylphenyl)methylidene]pyridine-3-carbohydrazide, N'-[(E)-[4-(methylsulfanyl)phenyl]methylidene]pyridine-3-carbohydrazide, N'-[(E)-[4-(dimethylamino)phenyl]methylidene]pyridine-3-carbohydrazide, N'-[(E)-phenylmethylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-nitrophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(4-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2,4-dihydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-ethoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3,4-diethoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3,4-dimethoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(4-ethoxy-3-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-hydroxy-5-methoxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-chlorophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-fluorophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2,4-dichlorophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-chloro-5-nitrophenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-(2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide, N'-[(E)-[4-(methylsulfanyl)phenyl]methylidene]pyridine-4-carbohydrazide, and N'-[(E)-[4-(dimethylamino)phenyl]methylidene]pyridine-4-carbohydrazide | Bos taurus | |
N'-[(E)-(2,4,6-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(2-bromophenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(2-fluorophenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(2-methylphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3,5-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3-chlorophenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3-chlorophenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3-nitrophenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(4-chlorophenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(4-chlorophenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-4-carbohydrazide | - |
Bos taurus | |
N'-[(E)-(4-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Bos taurus | |
N'-[(E)-phenylmethylidene]pyridine-3-carbohydrazide | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxanthine + NAD+ + H2O | Bos taurus | - |
xanthine + NADH + H+ | - |
? | |
xanthine + H2O + O2 | Bos taurus | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P80457 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Bos taurus | - |
milk | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxanthine + NAD+ + H2O | - |
Bos taurus | xanthine + NADH + H+ | - |
? | |
xanthine + H2O + O2 | - |
Bos taurus | urate + H2O2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0009 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(2,4,6-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide | |
0.01 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.0124 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3,4-dihydroxyphenyl)methylidene]pyridine-4-carbohydrazide | |
0.021 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-4-carbohydrazide | |
0.0211 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-phenylmethylidene]pyridine-3-carbohydrazide | |
0.055 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide | |
0.161 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3,5-dihydroxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.174 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(2-fluorophenyl)methylidene]pyridine-3-carbohydrazide | |
0.174 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide | |
0.1755 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.179 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(4-chlorophenyl)methylidene]pyridine-4-carbohydrazide | |
0.18 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(2-methylphenyl)methylidene]pyridine-3-carbohydrazide | |
0.184 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3-nitrophenyl)methylidene]pyridine-3-carbohydrazide | |
0.184 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(4-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.195 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(4-chlorophenyl)methylidene]pyridine-3-carbohydrazide | |
0.198 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(2-bromophenyl)methylidene]pyridine-3-carbohydrazide | |
0.205 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3-chlorophenyl)methylidene]pyridine-3-carbohydrazide | |
0.206 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3-chlorophenyl)methylidene]pyridine-4-carbohydrazide | |
0.242 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.264 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.33 | - |
pH 7.4, 30°C | Bos taurus | N'-[(E)-(4-ethoxyphenyl)methylidene]pyridine-4-carbohydrazide |