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Literature summary for 1.17.3.2 extracted from

  • Cao, H.; Hall, J.; Hille, R.
    Substrate Orientation and Specificity in Xanthine Oxidase: Crystal structures of the enzyme in complex with indole-3-acetaldehyde and guanine (2014), Biochemistry, 53, 533-541.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures for bovine xanthine oxidase in complex with indole-3-acetaldehyde and guanine, both at 1.6 A resolution is reported. In the case of indole-3-acetaldehyde, a modest, sterically allowed rotation juxtaposes the aldehyde group with the molybdenum center that allows hydroxylation to take place. With guanine, the substrate must rotate approximately 180° to present its 8 position to the active site molybdenum center for hydroxylation, and this rotation is sterically prohibited Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
milk enzyme isolated from Bos taurus
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Synonyms

Synonyms Comment Organism
xanthine oxidase
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Bos taurus