Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.3.2 extracted from

  • Nguyen, M.T.; Awale, S.; Tezuka, Y.; Ueda, J.Y.; Tran, Q.; Kadota, S.
    Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense (2006), Planta Med., 72, 46-51.
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
2-(3,4-dihydroxy-5-methoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one competitive, 50% inhibition at 0.00022 mM Bos taurus
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one competitive, 50% inhibition at 0.00124 mM Bos taurus
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one competitive, 50% inhibition at 0.00019 mM; competitive, 50% inhibition at 0.00020 mM Bos taurus
3,4-Dihydroxybenzaldehyde mixed type inhibition, 50% inhibition at 0.0568 mM Bos taurus
5,7-dihydroxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one competitive, 50% inhibition at 0.00051 mM Bos taurus
5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one competitive, 50% inhibition at 0.00133 mM Bos taurus
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one competitive, 50% inhibition at 0.00013 mM Bos taurus
5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6-dimethoxy-4H-chromen-4-one competitive, 50% inhibition at 0.00115 mM Bos taurus
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one competitive, 50% inhibition at 0.00036 mM Bos taurus
5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one competitive, 50% inhibition at 0.080016mM Bos taurus
acacetin 7-O-(3-O-acetyl-beta-D-glucopyranoside) flavone glucoside from Chrysanthemum sinense, 50% inhibition at 0.080 mM Bos taurus
allopurinol competitive, 50% inhibition at 0.0025 mM Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Bos taurus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00011
-
 5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00011
-
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00012
-
 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00015
-
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00015
-
 2-(3,4-dihydroxy-5-methoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00028
-
 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00037
-
 5,7-dihydroxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00079
-
 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6-dimethoxy-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.0009
-
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.00102
-
 5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one pH 7.5, 25°C Bos taurus
0.0018
-
 allopurinol pH 7.5, 25°C Bos taurus
0.0399
-
 3,4-Dihydroxybenzaldehyde pH 7.5, 25°C Bos taurus
0.0538
-
 acacetin 7-O-(3-O-acetyl-beta-D-glucopyranoside) pH 7.5, 25°C Bos taurus