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Literature summary for 1.17.3.2 extracted from

  • Frederiks, W.M.; Vreeling-Sindelarova, H.
    Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells (2002), Acta Histochem., 104, 29-37.
    View publication on PubMed
Search for more literature for 1.17.3.2

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information only XOR activity is present in the cytoplasm of rat liver parenchymal cells. In Kupffer cells and sinusoidal endothelial cell xanthine oxidoreductase activity is demonstrated in vesicles and occasionally on granular endoplasmic reticulum. Xanthine oxidase activity is not found in Kupffer cells and sinusoidal cells Rattus norvegicus
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peroxisome matrix and core of peroxisomes of liver parenchymal cells, xanthine oxidoreductase and xanthine oxidase detected Rattus norvegicus 5777
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Rattus norvegicus xanthine oxidoreductase, XOR, can exist in a dehydrogenase form, XD, and an oxidase form, XO. Part of total XOR activity in peroxisomes is XO activity. The major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of O2 radicals, but rather the production of uric acid which can act as a potent antioxidant urate + H2O2
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 xanthine oxidoreductase can exists in a dehydrogenase form, XD, and in an oxidase form, XO
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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parenchymal cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2
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 Rattus norvegicus urate + H2O2
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 ?
xanthine + H2O + O2 xanthine oxidoreductase, XOR, can exist in a dehydrogenase form, XD, and an oxidase form, XO. Part of total XOR activity in peroxisomes is XO activity. The major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of O2 radicals, but rather the production of uric acid which can act as a potent antioxidant Rattus norvegicus urate + H2O2
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 ?

Synonyms

Synonyms Comment Organism
xanthine oxidoreductase xanthine oxidoreductase can exists in a dehydrogenase form, XD, and an oxidase form, XO Rattus norvegicus
XO
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 Rattus norvegicus
XOR xanthine oxidoreductase can exists in a dehydrogenase form, XD, and an oxidase form, XO Rattus norvegicus