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Literature summary for 1.17.3.2 extracted from

  • Bray, R.C.
    Xanthine oxidase (1963), The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 7, 533-556.
No PubMed abstract available
Search for more literature for 1.17.3.2

General Stability

General Stability Organism
phosphate stabilizes Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1,2-Dihydroxybenzene 3,5-disulfonic acid inhibits reaction with cytochrome c Bos taurus
3,3',4,4'-Tetrahydroxychalcone
-
 Bos taurus
4-iminocyclohexa-2,5-dien-1-one
-
 Bos taurus
copper
-
 Bos taurus
hydroxylamine
-
 Bos taurus
myoglobin inhibits reaction with cytochrome c as acceptor Bos taurus
phenylhydrazine
-
 Bos taurus
Pterines or other heterocyclic compounds, which are either not oxidized or oxidized rather slowly Bos taurus
Purines
-
 Bos taurus
salicylate
-
 Bos taurus
Semicarbazide
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome enzyme from milk and mammary gland Bos taurus
-
-
additional information liver enzyme: in supernatant fraction Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron iron-molybdenum protein Bos taurus
Iron contains FAD, iron and molybdenum in the ratio 1/4/4 Bos taurus
Molybdenum contains FAD, molybdenum and iron in the ratio 1/4/4 Bos taurus
Molybdenum an iron-molybdenum protein Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Oxidation Stability

Oxidation Stability Organism
photooxidation, protection by competitive inhibitors Bos taurus

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information
-
 Bos taurus
proteolytic modification
-
 Bos taurus

Reaction

Reaction Comment Organism Reaction ID
xanthine + H2O + O2 = urate + H2O2 mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + 2 H2O + 2 O2
-
 Bos taurus urate + 2 H2O2
-
 ?
xanthine + H2O + O2 electron acceptor methylene blue Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor NAD+ Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor O2 Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 specificity for electron acceptor is low Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor triphenyltetrazolium chloride, phenazine methosulfate, nitrate, cytochrome c, ferritin Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 low specificity to substrate Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor ferricyanide Bos taurus uric acid + H2O2
-
 ?
xanthine + H2O + O2 electron acceptor 2,6-dichlorophenolindophenol Bos taurus uric acid + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Bos taurus
FAD contains FAD, molybdenum and iron in the ratio 1 : 4 : 4 Bos taurus