Literature summary for 1.17.1.4 extracted from

Shimo, T.; Ashizawa, N.; Moto, M.; Matsumoto, K.; Iwanaga, T.; Nagata, O.
FYX-051, a xanthine oxidoreductase inhibitor, induces nephropathy in rats, but not in monkeys (2009), Toxicol. Pathol., 37, 438-445.

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Inhibitors

Inhibitors	Comment	Organism	Structure
FYX-051	i.e. 4-(5-pyridin-4-yl-1H-[1, 2, 4]triazol-3-yl)pyridine-2-carbonitrile, a xanthine oxidoreductase inhibitor, that causes xanthine-mediated nephropathy inrats, but not in monkeys, toxicity study, overview	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
xanthine + NAD+ + H2O	Rattus norvegicus	-	urate + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male and female Crj:CD(SD)IGS rats and male Sprague-Dawley rats	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
xanthine + NAD+ + H2O	-	Rattus norvegicus	urate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
xanthine oxidoreductase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Rattus norvegicus

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Release 2023.1 (January 2023)