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Literature summary for 1.17.1.4 extracted from

  • Taibi, G.; Carruba, G.; Miceli, V.; Cocciadiferro, L.; Nicotra, C.M.
    Estradiol decreases xanthine dehydrogenase enzyme activity and protein expression in non-tumorigenic and malignant human mammary epithelial cells (2009), J. Cell. Biochem., 108, 688-692.
    View publication on PubMed
Search for more literature for 1.17.1.4

Inhibitors

Inhibitors Comment Organism Structure
17beta-estradiol inhibition of enzyme activity in malignant and non-malignant mammary epithelial cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast tumor cell
-
 Homo sapiens
-
mammary gland constitutive expression and high activity of XDH in non-malignant cells Homo sapiens
-
MCF-7 cell low XDH expression and activity Homo sapiens
-
MDA-MB-231 cell low XDH expression and activity Homo sapiens
-

Synonyms

Synonyms Comment Organism
XDH
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens downregulation of enzyme expression in malignant and non-malignant mammary epithelial cells by 17beta-estradiol down

General Information

General Information Comment Organism
malfunction the retinoic acid deficiency in breast tumour epithelial cells has been ascribed to an insufficient expression of either the enzyme(s) involved in its biosynthesis or the cellular retinol binding protein or both, overview Homo sapiens