Literature summary for 1.17.1.4 extracted from

Le, A.; Damico, R.; Damarla, M.; Boueiz, A.; Pae, H.H.; Skirball, J.; Hasan, E.; Peng, X.; Chesley, A.; Crow, M.T.; Reddy, S.P.; Tuder, R.M.; Hassoun, P.M.
Alveolar cell apoptosis is dependent on p38-MAPK-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury (2008), J. Appl. Physiol., 105, 1282-1290.

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Application

Application	Comment	Organism
medicine	xanthine oxidoreductase is activated in a p38 MAP kinase-dependent manner following high tidal volume mechanical ventilation and is involved in resulting increased alveolar cell apoptosis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
allopurinol	inhibition of xanthine oxidoreductase also suppresses high tidal volume mechanical ventilation-induced alveolar apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
alveolus	xanthine oxidoreductase is activated in a p38 MAP kinase-dependent manner following high tidal volume mechanical ventilation and is involved in resulting increased alveolar cell apoptosis	Homo sapiens	-

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Release 2023.1 (January 2023)