Literature summary for 1.16.1.9 extracted from

Escudero, R.; Gomez-Gallego, M.; Romano, S.; Fernandez, I.; Gutierrez-Alonso, A.; Sierra, M.A.; Lopez-Rayo, S.; Nadal, P.; Lucena, J.J.
Biological activity of Fe(III) aquo-complexes towards ferric chelate reductase (FCR) (2012), Org. Biomol. Chem., 10, 2272-2281.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Cucumis sativus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 Fe(II)-siderophore + NADP+ + H+	Cucumis sativus	-	2 Fe(III)-siderophore + NADPH	-	r

Organism

Organism	UniProt	Comment	Textmining
Cucumis sativus	-	cv. Ashley	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
root	-	Cucumis sativus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 Fe(II)-siderophore + NADP+ + H+	-	Cucumis sativus	2 Fe(III)-siderophore + NADPH	-	r
Fe(III)-o,o-EDDHA I + NADPH	i.e. ethylenediaminebis(o-hydroxyphenyl)acetic acid	Cucumis sativus	Fe(II)-o,o-EDDHA I + NADP+ + H+	-	?
additional information	the enzyme is able to effectively reduce synthetic ferric chelates, which are octahedral Fe(III) complexes derived from polyaminocarboxylic acids, the process requires the generation of a coordination vacancy in the Fe(III)L6 complex I and the incorporation of a water molecule, photometric titration, overview	Cucumis sativus	?	-	?

Synonyms

Synonyms	Comment	Organism
FCR	-	Cucumis sativus
ferric chelate reductase	-	Cucumis sativus

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	dependent on	Cucumis sativus
NADPH	dependent on	Cucumis sativus

General Information

General Information	Comment	Organism
physiological function	the process known as Strategy I, occurs in the rhizosphere and is mediated by the FRO2, a ferric chelate reductase enzyme. Once reduced, the Fe(II) is taken up into the cells by the IRT1, a specific transport system	Cucumis sativus

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Release 2023.1 (January 2023)