Cloned (Comment) | Organism |
---|---|
gene MTRR, genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | common naturally occuring polymorphisms are MTRR 66A>G or MTRR 524C>T, which affect the enzyme activity. Effects of the MTRR genotype on human status with respect to vitmain B6, plasma folate, homocysteine, and plasma cobalamine levels, modeling, detailed overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine | Homo sapiens | - |
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBK8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine | - |
Homo sapiens | 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Methionine synthase reductase | - |
Homo sapiens |
MTRR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | the C-terminal domain of MTRR binds FAD | Homo sapiens | |
FMN | the N-terminal domain of MTRR binds flavin mononucleotide | Homo sapiens | |
additional information | a riboflavin-dependent enzyme | Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme enzyme plays a key role in homocysteine metabolism | Homo sapiens |
additional information | effects of the MTRR genotype on human status with respect to vitmain B6, plasma folate, homocysteine, and plasma cobalamine levels, modeling, detailed overview | Homo sapiens |
physiological function | roles of methionine synthase, MS, and methylenetetrahydrofolate reductase, MTHFR, and methionine synthase reductase, MTRR, in the folate cycle and homocysteine remethylation, overview | Homo sapiens |