Application | Comment | Organism |
---|---|---|
diagnostics | the MTRR A66G polymorphism is a potential biomarker for cancer risk | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene MTRR, genotyping for the A66G polymorphism and analysis of the association with cancer risk, overview. The G allele and GG variant genotypes are associated with a significantly increased cancer risk | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A66G | naturally occuring mutation, the MTRR polymorphism leads to a lower affinity for substrate methionine synthase compared to the wild-type enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Methionine synthase reductase | - |
Homo sapiens |
MTRR | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the MTRR gene is involved in tumorigenesis by regulating DNA methylation through activation of methionine synthase | Homo sapiens |
additional information | genotyping for the A66G polymorphism and analysis of the association with cancer risk reveals that the G allele and GG variant genotypes are associated with a significantly increased cancer risk | Homo sapiens |