Application | Comment | Organism |
---|---|---|
medicine | variant M22/S175 is a genetic determinant of plasma homocysteine levels and has been linked to premature coronary artery disease, Downs syndrome, and neural tube defects | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
variant I22/L175 | - |
Homo sapiens | - |
variant M22/S175 | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | contains both FAD and FMN. The values of the midpoint potentials are -236 mV FAD oxidized/semiquinone and -264 mV FAD semiquinone/hydroquinone, variant M22/S175 | Homo sapiens | |
FAD | contains both FAD and FMN. The values of the midpoint potentials are -252 mV FAD oxidized/semiquinone and -285 mV FAD semiquinone/hydroquinone, variant I22/L175 | Homo sapiens | |
FMN | contains both FAD and FMN. The values of the midpoint potentials are -103 mV FMN oxidized/semiquinone and -175 mV FMN semiquinone/hydroquinone, variant I22/L175 | Homo sapiens | |
FMN | contains both FAD and FMN. The values of the midpoint potentials are -114 mV FMN oxidized/semiquinone and -212 mV FMN semiquinone/hydroquinone, variant M22/S175 | Homo sapiens |