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Literature summary for 1.16.1.8 extracted from

  • Leclerc, D.; Wilson, A.; Dumas, R.; Gafuik, C.; Song, D.; Watkins, D.; Heng, H.H.Q.; Rommens, J.M.; Scherer, S.W.; Rosenblatt, D.S.; Gravel, R.A.
    Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria (1998), Proc. Natl. Acad. Sci. USA, 95, 3059-3064.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.16.1.8

Application

Application Comment Organism
medicine cloning of the cDNA will permit the diagnostic characterization of cblE patients and investigation of the potential role of polymorphisms of this enzyme as a risk factor in hyperhomocysteinemia-linked vascular disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77000
-
 x * 77000, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[Methionine synthase]-cob(II)alamin + NADPH + S-adenosyl-L-methionine Homo sapiens the enzyme is involved in reductive activation of methionine synthase: ?
-
 ?
[Methionine synthase]-cob(II)alamin + NADPH + S-adenosyl-L-methionine Homo sapiens patients of the cblE complementation group of disorders of folate/cobalamin metabolism who are defective in reductive activation of methionine synthase exhibit megablastic anemia, developmental delay, hyperhomocysteinemia, and hypomethioninemia ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBK8 patients with homocystinuria
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[Methionine synthase]-cob(II)alamin + NADPH + S-adenosyl-L-methionine
-
 Homo sapiens [Methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + NADP+
-
 ?
[Methionine synthase]-cob(II)alamin + NADPH + S-adenosyl-L-methionine the enzyme is involved in reductive activation of methionine synthase: Homo sapiens ?
-
 ?
[Methionine synthase]-cob(II)alamin + NADPH + S-adenosyl-L-methionine patients of the cblE complementation group of disorders of folate/cobalamin metabolism who are defective in reductive activation of methionine synthase exhibit megablastic anemia, developmental delay, hyperhomocysteinemia, and hypomethioninemia Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 77000, calculation from nucleotide sequence Homo sapiens