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Literature summary for 1.16.1.2 extracted from

  • Sun, I.L.; Navas, P.; Crane, F.L.; Morre, D.J.; Löw, H.
    NADH diferric transferrin reductase in liver plasma membrane (1987), J. Biol. Chem., 262, 15915-15921.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate detergent, activates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
adriamycin
-
Rattus norvegicus
amiloride
-
Rattus norvegicus
apotransferrin
-
Rattus norvegicus
Atebrin
-
Rattus norvegicus
Chloroquinone
-
Rattus norvegicus
additional information sensitive to treatment with trypsin Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0061
-
NADH
-
Rattus norvegicus
0.033
-
Transferrin[Fe(II)]2
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane
-
Rattus norvegicus
-
-
additional information low activity in the membranes of Golgi apparatus, endoplasmic reticulum and mitochondria, about 10% of the activity in the plasma membrane Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ potassium phosphate buffer leads to a slightly higher activity than sodium phosphate buffer Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
transferrin[Fe(III)]2 + NADH Rattus norvegicus reduction of diferric transferrin at the cell surface may be an important function for diferric transferrin in stimulation of cell growth transferrin[Fe(II)]2 + NAD+
-
?
transferrin[Fe(III)]2 + NADH Rattus norvegicus role in iron transport transferrin[Fe(II)]2 + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0057
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferritin[Fe(III)] + NADH
-
Rattus norvegicus ferritin[Fe(II)] + NAD+
-
?
transferrin[Fe(II)]2 + NAD+ + H+
-
Rattus norvegicus transferrin[Fe(III)]2 + NADH
-
r
transferrin[Fe(III)]2 + NADH
-
Rattus norvegicus transferrin[Fe(II)]2 + NAD+
-
?
transferrin[Fe(III)]2 + NADH reduction of diferric transferrin at the cell surface may be an important function for diferric transferrin in stimulation of cell growth Rattus norvegicus transferrin[Fe(II)]2 + NAD+
-
?
transferrin[Fe(III)]2 + NADH role in iron transport Rattus norvegicus transferrin[Fe(II)]2 + NAD+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7 10 pH 7.0: about 40% of activity maximum, pH 10.0: about 35% of activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH preferred electron donor Rattus norvegicus
NADPH about 50% of the activity with NADH Rattus norvegicus