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Literature summary for 1.15.1.1 extracted from
- Functional expression and characterization of a cytosolic copper/zinc-superoxide dismutase of Spirometra erinacei (2010), Parasitol. Res., 106, 627-635.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene SeCuZnSOD, DNA and amino acid sequence determination and analysis, genomic organization, sequence alignment and phylogenetic analysis, quantitative RT-PCR expression analysis, recombinant expression as GST-tagged enzyme in Escherichia coli | Spirometra erinaceieuropaei |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H2O2 | - |
Spirometra erinaceieuropaei |  |
| KCN | - |
Spirometra erinaceieuropaei | |
| additional information | no inhibition by NaN3 | Spirometra erinaceieuropaei |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Spirometra erinaceieuropaei | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | a CuZn-superoxide dismutase | Spirometra erinaceieuropaei | |
| Zn2+ | a CuZn-superoxide dismutase | Spirometra erinaceieuropaei | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 15800 | - |
2 * 42000, recombinant GST-tagged SeCuZnSOD, SDS-PAGE, 2 * 15800, untagged enzyme, SDS-PAGE | Spirometra erinaceieuropaei |
| 30000 | - |
untagged enzyme, gel filtration | Spirometra erinaceieuropaei |
| 42000 | - |
2 * 42000, recombinant GST-tagged SeCuZnSOD, SDS-PAGE, 2 * 15800, untagged enzyme, SDS-PAGE | Spirometra erinaceieuropaei |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Spirometra erinaceieuropaei | Q6B7T0 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant GST-tagged SeCuZnSOD from Escherichia coli by glutathione affinity chromatography | Spirometra erinaceieuropaei |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| larva | - |
Spirometra erinaceieuropaei | - |
| additional information | constant expression in plerocercoid larvae and adult worms | Spirometra erinaceieuropaei | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 42000, recombinant GST-tagged SeCuZnSOD, SDS-PAGE, 2 * 15800, untagged enzyme, SDS-PAGE | Spirometra erinaceieuropaei |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| copper/zinc-superoxide dismutase | - |
Spirometra erinaceieuropaei |
| CuZn-SOD | - |
Spirometra erinaceieuropaei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
broad pH optimum | Spirometra erinaceieuropaei |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9.5 | - |
Spirometra erinaceieuropaei |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Spirometra erinaceieuropaei | the expression of the enzyme is increased in plerocercoid larvae after treated with paraquat and significantly induced under oxidative stress | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme may play essential roles for survival of the parasite not only by protecting itself from endogenous oxidative stress, but also by detoxifying oxidative killing of the parasite by host immune effector cells | Spirometra erinaceieuropaei |
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