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Literature summary for 1.15.1.1 extracted from

  • McAtee, B.; Yager, J.
    Manganese superoxide dismutase: Effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts (2010), Mol. Cell. Biochem., 335, 107-118.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, ala16val polymorphism genotyping, overview, stably expression of human MnSOD-A16 and MnSOD-V16 variants in mouse fibroblasts Homo sapiens

Protein Variants

Protein Variants Comment Organism
A16V naturally occuring ala16val polymorphism genotyping, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix MnSOD is translated in the cytoplasm and then imported into the mitochondria via a mitochondrial targeting signal Homo sapiens 5759
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ MnSOD Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 O2.- + 2 H+ + Homo sapiens
-
O2 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P04179
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell harbors MnSOD with the ala16val polymorphism Homo sapiens
-
HCC-38 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
T-47D cell
-
Homo sapiens
-
ZR-75-1 cell
-
Homo sapiens
-
ZR-75-30 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 O2.- + 2 H+ +
-
Homo sapiens O2 + H2O2
-
?

Synonyms

Synonyms Comment Organism
manganese superoxide dismutase
-
Homo sapiens
MnSOD
-
Homo sapiens

General Information

General Information Comment Organism
malfunction MnSOD ala16val polymorphism is associated with various diseases including breast cancer Homo sapiens