Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, ala16val polymorphism genotyping, overview, stably expression of human MnSOD-A16 and MnSOD-V16 variants in mouse fibroblasts | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A16V | naturally occuring ala16val polymorphism genotyping, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | MnSOD is translated in the cytoplasm and then imported into the mitochondria via a mitochondrial targeting signal | Homo sapiens | 5759 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | MnSOD | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 O2.- + 2 H+ + | Homo sapiens | - |
O2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04179 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | harbors MnSOD with the ala16val polymorphism | Homo sapiens | - |
HCC-38 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
ZR-75-1 cell | - |
Homo sapiens | - |
ZR-75-30 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 O2.- + 2 H+ + | - |
Homo sapiens | O2 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
manganese superoxide dismutase | - |
Homo sapiens |
MnSOD | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | MnSOD ala16val polymorphism is associated with various diseases including breast cancer | Homo sapiens |