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Literature summary for 1.15.1.1 extracted from

  • Broeyer, F.J.; van Aken, B.E.; Suzuki, J.; Kemme, M.J.; Schoemaker, H.C.; Cohen, A.F.; Mizushima, Y.; Burggraaf, J.
    The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man (2008), Br. J. Clin. Pharmacol., 65, 22-29.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of the CuZn-SOD in Escherichia coli Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a CuZn-SOD Homo sapiens
Zn2+ a CuZn-SOD Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens pharmacokinetics, safety and tolerability of single rising doses up to 80 mg of recombinant human superoxide dismutase covalently linked to lecithin in healthy white volunteers, overview ?
-
?
O2.- + H+ Homo sapiens
-
O2 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information measurement of serum and urinary PC-Cu,Zn-SOD concentrations after application of exogenous recombinant human isozyme to male and female humans, overview Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
SOD activity profile after intravenous administration of Cu,Zn-SOD covalently linked to lecithin, measurement of serum and urinary PC-Cu,Zn-SOD concentrations after application of exogenous recombinant human isozyme to male and female humans, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pharmacokinetics, safety and tolerability of single rising doses up to 80 mg of recombinant human superoxide dismutase covalently linked to lecithin in healthy white volunteers, overview Homo sapiens ?
-
?
O2.- + H+
-
Homo sapiens O2 + H2O2
-
?

Synonyms

Synonyms Comment Organism
CuZn-SOD
-
Homo sapiens
SOD
-
Homo sapiens