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Literature summary for 1.15.1.1 extracted from

  • Keith, K.E.; Valvano, M.A.
    Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia (2007), Infect. Immun., 75, 2451-2460.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene sodC, subcloning in Escherichia coli, complementation of the sodC mutant, expression of a SodC-FLAG fusion protein in strain K56-2 Burkholderia cenocepacia

Protein Variants

Protein Variants Comment Organism
additional information enzyme null mutant cell is not sensitive to H2O2, 3-morpholinosydnonimine, or paraquat challenge, but is killed by exogenous superoxide generated by the xanthine/xanthine oxidase method Burkholderia cenocepacia
additional information construction of a sodC null mutant strain KEK1, which is not sensitive to a H2O2, 3-morpholinosydnonimine, or paraquat challenge, but is killed by exogenous superoxide generated by the xanthine/xanthine oxidase method. The sodC mutant also exhibits a growth defect in liquid medium compared to the parental strain, which can be complemented in trans. The mutant organism is killed more rapidly than the parental strain in murine macrophage-like cell line RAW 264.7, but killing is eliminated when macrophages are treated with an NADPH oxidase inhibitor, overview Burkholderia cenocepacia

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme is not inhibited by H2O2 and unusually resistant to KCN; SodC is resistant to inhibition by H2O2 and is unusually resistant to KCN for a Cu,Zn-SOD Burkholderia cenocepacia

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
-
 Burkholderia cenocepacia
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
copper
-
 Burkholderia cenocepacia
Cu2+ a Cu,ZnSOD Burkholderia cenocepacia
Zinc
-
 Burkholderia cenocepacia
Zn2+ a Cu,ZnSOD Burkholderia cenocepacia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O2.- + H+ Burkholderia cenocepacia periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages O2 + H2O2
-
 ?
O2.- + H+ Burkholderia cenocepacia K56-2 periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages O2 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Burkholderia cenocepacia
-
-
-
Burkholderia cenocepacia K56-2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O2.- + H+
-
 Burkholderia cenocepacia O2 + H2O2
-
 ?
O2.- + H+ periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages Burkholderia cenocepacia O2 + H2O2
-
 ?
O2.- + H+
-
 Burkholderia cenocepacia K56-2 O2 + H2O2
-
 ?
O2.- + H+ periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages Burkholderia cenocepacia K56-2 O2 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
Cu,ZnSOD
-
 Burkholderia cenocepacia
SodC
-
 Burkholderia cenocepacia