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Literature summary for 1.14.99.50 extracted from

  • Seebeck, F.P.
    In vitro reconstitution of Mycobacterial ergothioneine biosynthesis (2010), J. Am. Chem. Soc., 132, 6632-6633.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Mycolicibacterium smegmatis

Inhibitors

Inhibitors Comment Organism Structure
EDTA
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Mycolicibacterium smegmatis

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ requires Fe2+ for activity Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hercynine + gamma-L-glutamyl-L-cysteine + O2 Mycolicibacterium smegmatis the enzyme is part of the biosynthesis pathway of ergothioneine gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
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?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R5N0
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hercynine + gamma-L-glutamyl-L-cysteine + O2 the enzyme is part of the biosynthesis pathway of ergothioneine Mycolicibacterium smegmatis gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
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?
hercynine + gamma-L-glutamyl-L-cysteine + O2 hercynine i.e. Nalpha,Nalpha,Nalpha-trimethyl-L-histidine. The enzyme is specific for both hercynine and gamma-L-glutamyl-L-cysteine. No activity with cysteine, N-acetylcysteine, or glutathione Mycolicibacterium smegmatis gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
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?

Synonyms

Synonyms Comment Organism
EgtB
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Mycolicibacterium smegmatis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
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assay at Mycolicibacterium smegmatis

General Information

General Information Comment Organism
metabolism the enzyme is part of the biosynthesis pathway of ergothioneine Mycolicibacterium smegmatis