Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.99.39 extracted from

  • Keener, W.K.; Arp, D.J.
    Kinetic studies of ammonia monooxygenase inhibition in Nitrosomonas europaea by hydrocarbons and halogenated hydrocarbons in an optimized whole-cell assay (1993), Appl. Environ. Microbiol., 59, 2501-2510.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Bromoethane noncompetitive Nitrosomonas europaea
chloroethane noncompetitive Nitrosomonas europaea
Chloromethane noncompetitive Nitrosomonas europaea
chloropropane noncompetitive Nitrosomonas europaea
ethane noncompetitive Nitrosomonas europaea
ethylene competitive Nitrosomonas europaea
Iodoethane noncompetitive Nitrosomonas europaea
iodomethane noncompetitive Nitrosomonas europaea
methane competitive Nitrosomonas europaea
additional information active-site model for ammonia monooxygenase consisting of an NH3-binding site and a second site that binds noncompetitive inhibitors, with oxidation occurring at either site Nitrosomonas europaea
n-butane noncompetitive Nitrosomonas europaea
n-chloropropane noncompetitive Nitrosomonas europaea
propane noncompetitive Nitrosomonas europaea

Organism

Organism UniProt Comment Textmining
Nitrosomonas europaea
-
-
-

Reaction

Reaction Comment Organism Reaction ID
NH3 + a reduced acceptor + O2 = NH2OH + an acceptor + H2O mechanism, active-site model for ammonia monooxygenase consisting of an NH3-binding site and a second site that binds noncompetitive inhibitors, with oxidation occurring at either site Nitrosomonas europaea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ammonia + AH2 + O2
-
Nitrosomonas europaea NH2OH + A + H2O
-
?
additional information active-site model for ammonia monooxygenase consisting of an NH3-binding site and a second site that binds noncompetitive inhibitors, with oxidation occurring at either site Nitrosomonas europaea ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.03
-
iodomethane value derived from intercept replot Nitrosomonas europaea
0.03
-
Iodoethane value derived from intercept replot Nitrosomonas europaea
0.13
-
iodomethane value derived from slope replot Nitrosomonas europaea
0.22
-
Bromoethane value derived from intercept replot Nitrosomonas europaea
0.22
-
ethane value derived from slope replot Nitrosomonas europaea
0.29
-
Iodoethane value derived from slope replot Nitrosomonas europaea
0.3
-
n-butane value derived from intercept replot Nitrosomonas europaea
0.3
-
Chloromethane value derived from slope replot Nitrosomonas europaea
0.44
-
propane value derived from intercept replot Nitrosomonas europaea
0.49
-
Bromoethane value derived from slope replot Nitrosomonas europaea
0.5
-
chloropropane value derived from slope replot Nitrosomonas europaea
0.5
-
n-chloropropane value derived from slope replot Nitrosomonas europaea
0.66
-
ethylene value derived from slope replot Nitrosomonas europaea
0.89
-
ethane value derived from intercept replot Nitrosomonas europaea
0.92
-
n-butane value derived from slope replot Nitrosomonas europaea
1.01
-
chloroethane value derived from intercept replot Nitrosomonas europaea
1.41
-
chloroethane value derived from slope replot Nitrosomonas europaea
1.42
-
chloroethane value derived from intercept replot Nitrosomonas europaea
1.43
-
propane value derived from slope replot Nitrosomonas europaea
1.47
-
Chloromethane value derived from intercept replot Nitrosomonas europaea
1.49
-
chloropropane value derived from intercept replot Nitrosomonas europaea
1.49
-
n-chloropropane value derived from intercept replot Nitrosomonas europaea
3.24
-
methane value derived from slope replot Nitrosomonas europaea
5.15
-
chloroethane value derived from slope replot Nitrosomonas europaea