Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-amino-2-hydroxy-N-(propan-2-yl)benzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 7.6fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
5-amino-2-hydroxy-N-(propan-2-yl)benzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 7.6fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
5-amino-N-cyclohexyl-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 44fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
5-amino-N-cyclohexyl-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 44fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
5-amino-N-hexyl-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 44fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
5-amino-N-hexyl-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 44fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 29.7fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 29.7fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
indomethacin | - |
Homo sapiens | |
indomethacin | - |
Ovis aries | |
N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 135fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 135fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 120fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 120fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 114fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 114fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries | |
N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 145fold selectivity for isoform Cox-2 over Cox-1 | Homo sapiens | |
N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | 5-aminosalicylic acid derivative, additionally inhibits lipoxygenase Lox-5. 145fold selectivity for isoform Cox-2 over Cox-1 | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Ovis aries | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
COX-1 | - |
Ovis aries |
COX-2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000041 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | indomethacin | |
0.0001 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | |
0.0001 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | |
0.00011 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide | |
0.00011 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | |
0.00019 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 5-amino-N-cyclohexyl-2-hydroxybenzamide | |
0.00022 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 5-amino-N-hexyl-2-hydroxybenzamide | |
0.00033 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide | |
0.00039 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | 5-amino-2-hydroxy-N-(propan-2-yl)benzamide | |
0.00051 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | indomethacin | |
0.00298 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | 5-amino-2-hydroxy-N-(propan-2-yl)benzamide | |
0.0083 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | 5-amino-N-cyclohexyl-2-hydroxybenzamide | |
0.0097 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | 5-amino-N-hexyl-2-hydroxybenzamide | |
0.0098 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide | |
0.0126 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | |
0.0132 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide | |
0.0135 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide | |
0.0145 | - |
pH 7.4, temperature not specified in the publication | Ovis aries | N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide |