KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
arachidonate | purified isoform PGHS-2, method: coupled, homo-vanilic acid | Homo sapiens | |
0.0011 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.0017 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.0019 | - |
arachidonate | purified isoform PGHS-1, method: direct, O2 | Ovis aries | |
0.002 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.0027 | - |
arachidonate | purified isoform PGHS-1, method: coupled, homo-vanilic acid | Ovis aries | |
0.003 | - |
arachidonate | purified isoform PGHS-1, method: direct, O2 | Ovis aries | |
0.0037 | - |
arachidonate | purified isoform PGHS-1, method: direct, O2 | Ovis aries | |
0.0045 | - |
arachidonate | purified isoform PGHS-1, method: direct, O2 | Homo sapiens | |
0.005 | - |
O2 | purified isoform PGHS-1, method: direct, O2 | Ovis aries | |
0.005 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.0051 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.0055 | - |
O2 | purified isoform PGHS-1, method: direct, O2 | Ovis aries | |
0.009 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.0092 | - |
arachidonate | purified isoform PGHS-2, method: direct, O2 | Homo sapiens | |
0.01 | - |
O2 | purified isoform PGHS-1, method: direct, arachidonate | Ovis aries | |
0.01 | - |
arachidonate | purified isoform PGHS-2, method: direct, arachidonate | Homo sapiens | |
0.01 | - |
arachidonate | purified isoform PGHS-2, method: direct, trimethyl phosphine oxide | Homo sapiens | |
0.0102 | - |
arachidonate | purified isoform PGHS-1, method: direct, arachidonate | Homo sapiens | |
0.011 | - |
arachidonate | purified isoform PGHS-1, method: coupled, homo-vanilic acid | Ovis aries | |
0.011 | - |
O2 | purified isoform PGHS-1, method: direct, O2 | Ovis aries | |
0.015 | - |
arachidonate | purified isoform PGHS-1, method: direct, O2 | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23219 | - |
- |
Homo sapiens | P35354 | - |
- |
Ovis aries | P05979 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | the reaction comprises two steps: dioxygenation of arachidonate to yield prostaglandin G2 containing both a 9-11 endoperoxide and a 15-peroxide group, and a peroxidase reaction, which converts prostaglandin G2 to prostaglandin H2 where the 15-peroxide is reduced to an alcohol | Homo sapiens | prostaglandin H2 + A + H2O | - |
? | |
arachidonate + AH2 + O2 | the reaction comprises two steps: dioxygenation of arachidonate to yield prostaglandin G2 containing both a 9-11 endoperoxide and a 15-peroxide group, and a peroxidase reaction, which converts prostaglandin G2 to prostaglandin H2 where the 15-peroxide is reduced to an alcohol | Ovis aries | prostaglandin H2 + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGHS-1 | isoform | Ovis aries |
PGHS-1 | isoform | Homo sapiens |
PGHS-2 | isoform | Homo sapiens |
prostaglandin H synthase | - |
Homo sapiens |
prostaglandin H synthase | - |
Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens | |
heme | - |
Ovis aries |