Cloned (Comment) | Organism |
---|---|
expressed in COS-1 cells | Homo sapiens |
into the mammalian expression vector pcDNA3 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K211A | complete abolition of activity | Homo sapiens |
K211A/K215A | complete abolition of activity | Homo sapiens |
K211A/K215A/K222A | complete abolition of activity | Homo sapiens |
K211A/K222A | complete abolition of activity | Homo sapiens |
K211E | complete abolition of activity | Homo sapiens |
K211E/K215E | complete abolition of activity | Homo sapiens |
K211E/K215E/K222E | complete abolition of activity | Homo sapiens |
K211E/K222E | complete abolition of activity | Homo sapiens |
K215A | does not impair PGHS activity | Homo sapiens |
K215A/K222A | significant reduction of 27% of the activity | Homo sapiens |
K215E | does not impair PGHS activity | Homo sapiens |
K215E/K222E | significant reduction of 58% of the activity | Homo sapiens |
K222A | no significant reduction of activity | Homo sapiens |
K222E | no significant reduction of activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aspirin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
a homology modeling structure of human PGHS-1 is constructed using the Swiss-Model server and the ovine crystal structure 1Q4G as template | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COX1 | - |
Homo sapiens |
PGHS | - |
Homo sapiens |
PGHS-1 | - |
Homo sapiens |
prostaglandin endoperoxide H synthase-1 | - |
Homo sapiens |
prostaglandin endoperoxide synthase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
enzyme-linked immunoassay for PGE2 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |